Domain Of Unknown Function

A domain of unknown function duf is a protein domain that has no characterised function.

Domain of unknown function. Given their wide taxonomic distribution including bacterial pathogens many dufs are likely biologically essential. These families have been collected together in the pfam database using the prefix duf followed by a number with examples being duf2992 and duf1220. These families have been collected together in the pfam database using the prefix duf followed by a number with examples being duf2992 and duf1220.

A domain of unknown function is found at the n terminus of galt1 which belongs to an uncharacterized duf1792 superfamily cl07392. 1 consisting of an n terminal gtpase domain a middle domain of unknown function a ph domain that binds pi4 5p 2 a gtpase effector domain ged that functions in dynamin self assembly and assembly stimulated gtpase activity and a c terminal proline and arginine rich domain prd that interacts with numerous sh3 domain containing partners 4. As of 2019 there are almost 4 000 duf families within the pfam database representing over 22 of known families.

Thus reliable experimental identification of the in vitro enzymatic activities and in vivo physiological functions for the duf families is important. In release 29 0 3 892 families are annotated as a domain of unknown function duf because no member has an experimentally characterized function. A domain of unknown function duf is a protein domain that has no characterised function.

Duf1792 superfamily commonly found at the c terminus of proteins that also contain the glycosyltransferase domain at the n terminus. Recently numerous proteins containing the domain of unknown function duf 3494 were found to bind ice crystals and hence are classified as ibps. Ice binding proteins ibps control the growth and shape of ice crystals to cope with subzero temperatures in psychrophilic and freeze tolerant organisms.

A domain of unknown function duf is a protein domain that has no characterised function.