Topological Domain Biology Definition

The constraint might result from a pair of physical clamps attaching the dna at specialized sites or from restrained rotation of one strand of the double helix around the other in the viscous cellular environment. The median size of a tad in mouse cells is 880 kb and they have similar sizes in non mammalian species. A canonical example of a topological domain is circular dna which is typical of bacteria mitochondria chloroplasts many viruses etc.

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What Is A Topological Domain Biology Stack Exchange

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A topologically associating domain tad is a self interacting genomic region meaning that dna sequences within a tad physically interact with each other more frequently than with sequences outside the tad.

Topological domain biology definition. 1 consequently dna within a topological domain can be subjected to. By definition the formation of a topological domain requires topologically constrained dna. A dna segment constrained so that the free rotation of its ends is impossible is called a topological domain figure 2.

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