Sh Domain Biology

1 to identify proteins that bind to this motif sh3 domain arrays derived from human proteins were screened using an overlay assay tian et al 2006.

Sh domain biology. It has also been identified in several other protein families such as. 7 1 cortical actin binding protein. This domain is also present in the molecules of phospholipase and several cytoplasmic tyrosine kinases such as abl and src.

Sh2 domains are commonly found in adaptor proteins that aid in the signal transduction of receptor tyrosine. A noncanonical sh3 domain binding motif is positioned between the rck1 and rck2 domains of the bk channel α subunit fig. Initially sh3 was described as a conserved sequence in the viral adaptor protein v crk.

The sh2 src homology 2 domain is a structurally conserved protein domain contained within the src oncoprotein and in many other intracellular signal transducing proteins. Four species of sh have been detected in infected cell cytoplasm. Oh in international review of neurobiology 2016.

A 7 5 kda non glycosylated form sh0 a 13 15 kda form that contains one or two n linked carbohydrate side chains of the high mannose type shg a 21 30 kda polylactosaminoglycan modified form of the protein shp and the isoform generated by alternative translational initiation. Sh2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins.