Math Domain Traf

Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors extracellular matrix proteins and biologically active peptides.

Math domain traf. A ring finger in the n terminal part of the protein one to seven traf zinc fingers in the middle and the math domain in the c terminal part pubmed 12387856. Most human trafs traf1 6 contain a conserved c terminal region of about 180 residues known as the traf or math domain sometimes also designated as the traf c or the meprin homology domain. The math domain is necessary and sufficient for self association and receptor interaction.

Math meprin and traf c homology domain. A coiled coil region adjacent to the math domain is also. The tnf receptor associated factor traf domain td also known as the meprin and traf c homology math domain is a fold of seven anti parallel ß helices that participates in protein protein interactions.

The traf proteins are composed of 3 structural domains. There are virtually no structural changes in the traf domain upon binding to peptides from these interaction partners with only a slight shift of the side chain of trp165. The tnf receptor associated factor traf domain td also known as the meprin and traf c homology math domain is a fold of seven anti parallel p helices that participates in protein protein interactions.

Through structural analysis two consensus sequences recognised by the traf domain have been defined. An independent folding unit with an eight stranded beta sandwich structure found in meprins trafs and other proteins. A major one psat x qe e and a minor one pxqxxd.

The n terminal traf math domain comprises an eight stranded anti parallel β sandwich and is responsible for recruitment of substrates such as p53 and hdm2 and tspyl5 6 7 13. This fold is broadly represented among eukaryotes where it is found associated with a discrete set of protein domains. This fold is broadly represented among eukaryotes where it is found associated with a discrete set of protein domains.

Bric a brac tramtrack broad complex btb domain with meprin and traf homology math domain. This domain consists of seven or eight anti parallel β strands that participate in protein protein. The domain forms a new light stranded antiparallel beta sandwich structure.