Math Domain Protein

Extracellular protein in homo sapiens that is encoded by the prr36 proline rich region 36 gene that contains a domain of unknown function duf4596 towards the c terminus of the protein.

Math domain protein. Math meprin and traf c homology domain. The math domain in molecular biology is a binding domain that was defined originally by a region of homology between otherwise functionally unrelated domains the intracellular traf c domains of traf proteins and a c terminal region of extracellular meprins a and b. A ring finger in the n terminal part of the protein one to seven traf zinc fingers in the middle and the math domain in the c terminal part pubmed 12387856.

As the genome of a higher eukaryote the nematode. Spop is an e3 ubiquitin ligase adaptor protein that binds pdx1 thus triggering its ubiquitination and proteasomal degradation. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors extracellular matrix proteins and biologically.

The math domain is necessary and sufficient for self association and receptor interaction. Math proteins are involved in nodule formation in medicago and protein degradation in the arabidopsis cytosol. An independent folding unit with an eight stranded beta sandwich structure found in meprins trafs and other proteins.

Unknown but high gene expression has been observed in various regions of the brain such as the prefrontal cortex cerebellum and the amygdala. They exhibit sequence similarities to meprins extracellular peptidases which cleave signal peptides and to trafs intracellular proteins. Spop was isolated as a novel antigen recognized by serum from a scleroderma patient whose overexpression in cos cells results in a discrete speckled pattern in the nuclei.

We show that pdx1 residues 223 233 bind to spop math domain with low micromolar affinity. Composed of proteins with similarity to human spop. Math domain and coiled coil domain containing protein at1g31390.

Speckle type poz protein spop family math domain. A math meprin and traf tumour necrosis factor receptor associated factor homology domain containing math protein at the plasma membrane of arabidopsis roots is one of the first components to respond to the presence of this fungus. Here we present the crystal structure of the spop pdx1 complex.